ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2016, Vol. 47 ›› Issue (5): 1001-1008.doi: 10.11843/j.issn.0366-6964.2016.05.018

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Pharmacokinetics and Bioavailability of Diclofenac Sodium Injection in Swine

YANG Hai-feng1，2，LI Yong-jun1，WANG Ya-qin2，ZHAO Shan-shan1，DONG Hao1，BU Shi-jin2*   

  1. (1.Jiangsu Agri-animal Husbandry Vocational College， Taizhou 225300，China；2.College of Veterinary Medicine，Yangzhou University， Yangzhou 225009，China)
  • Received:2015-10-14 Online:2016-05-23 Published:2016-05-23

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Abstract:

Pharmacokinetics and bioavailability of diclofenac sodium injection were investigated in swine.A single intravenous (i.v.) or intramuscular (i.m.) administration of 5% diclofenac sodium injection at a dosage of 2.5 mg•kg-1 was performed in eight healthy pigs according to a two-period crossover design.The concentration of diclofenac sodium in plasma was determined by a high performance liquid chromatography method (HPLC).The pharmacokinetic parameters were calculated by non-compartmental analysis with DAS 2.1.1 software.The main pharmacokinetic parameters of diclofenac sodium injection in swine after a single intravenous administration were as follows：the elimination half time (T1/2β) was (1.32±0.34) h，area under the curve (AUC) was (55.50±5.50) (μg•mL-1)•h，mean residence time (MRT) was (1.60±0.28) h，apparent volume of distribution (Vd) was (0.50±0.05) L•kg-1，body clearance (CLB) was (0.26±0.04) L•(h•kg)-1.The main pharmacokinetic parameters of diclofenac sodium injection in swine after a single intramuscular administration were as follows：peak time (Tmax) was (1.19±0.26) h，peak concentration (Cmax) was (11.61±5.99) μg•mL-1，T1/2β was (1.87±0.70) h，AUC was (43.17±7.77) (μg•mL-1)•h，MRT was (2.86±0.64) h，bioavailability (F) was (78.29±14.81)%.The results showed that the diclofenac sodium injection have pharmacokinetic characteristics of rapid absorption and elimination，high peak concentration and bioavailability in swine，and the clinical recommended dosage of diclofenac sodium injection is 2.5 mg•kg-1.

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